Jobs And Other Opportunities
Post-doctoral position in computational biology of glioma , Luxembourg
Luxembourg Institute of Health (LIH) is the leading public research center in Luxembourg for basic, pre-clinical and clinical research in biomedicine and public health. Our clinically-oriented biomedical research activities in Oncology, Infection & Immunity and Population Health encompass the generation of knowledge on the pathogenesis, diagnosis and treatment of diseases with large impacts on public health and the epidemiological surveillance of these diseases. With the mission to deliver scientific, economic and societal value for Luxembourg, LIH aims to translate knowledge into clinical applications impacting on healthcare systems while shaping personalized medicine.
To be part of the NORLUX Neuro-Oncology Laboratory (Group leaders: Prof Simone Niclou and Dr. Anna Golebiewska) within the Department of Oncology at the LIH, we are currently looking for:
Post-doctoral position in computational biology of glioma
3-year fixed-term contract, full time. Start date: April 2021.
Background. Gliomas are malignant brain tumours that undergo cellular and molecular evolution during disease progression, which is only partially explained by genetic evolution, suggesting that transcriptional and epigenetic changes may be the basis of cellular adaptation processes. The international GLASS (Glioma Longitudinal AnalySiS) initiative, aims to systematically catalogue the temporal changes in gliomas at the genetic, epigenetic and transcriptomic levels. In this context, NORLUX aims to assess differential functional drug responses of primary versus recurrent gliomas.
Objectives. Based on this broader context, the NORLUX lab is looking for a computational scientist with strong interest in cancer biology to conduct an integrative multiomics data analysis (DNA-Seq, methylation, RNA-Seq), linking the results to pharmacogenomics outcomes. The objective is to identify differences in drug sensitivity in paired longitudinal tumours and predict personalized treatment options for recurrent glioma patients.
Training and research environment. The NORLUX lab is a dynamic, multinational and interdisciplinary team focusing on the biology of malignant brain tumours. It is a part of the Department of Oncology and uses cutting-edge technologies, including genomic, metabolomic and proteomic analyses, single cell technologies (single cell RNA-Seq, CYTOF, Imagestream) as well as state-of-the-art preclinical models. The project will be performed in collaboration with the international GLASS consortium (www.glass-consortium.org/). The post-doctoral fellow will be supported through a FNR CORE funded project and will join an interdisciplinary project team, including cellular and molecular biologists, animal experts, bioinformaticians and statisticians. Recent related reference: https://pubmed.ncbi.nlm.nih.gov/33009951/
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as opportunities for conference attendance and collaborations with other research organisations.
Scientific contact
Prof Simone Niclou, PhD
84 Val Fleuri
L-1526 Luxembourg
LUXEMBOURG
simone.niclou@lih.lu
Key Skills, Experience and Qualifications
- PhD in computational biology, bioinformatics, genomics, systems biology or a related field with prior experience in cancer research.
- Expertise in computational and statistical analysis of at least two of the considered technologies (RNA-Seq, methylation, DNA-Seq) is required. Experience in analysis of single cell RNA-Seq data is an asset.
- Understanding of common bioinformatics approaches and extensive experience with one of the main programming languages for data analysis (R, Python). Knowledge in other programming languages and data analysis tools is an asset.
- Independent and self-motivated person, scientific creativity and originality, strong team spirit and collaborative capacity, excellent time management, rigor, perseverance, strong writing skills.
- Fluency in English is mandatory
More information about the group can be found here : https://norlux.lih.lu
Located in Luxembourg, LIH offers the opportunity to work in a dynamic, international and multilingual
environment that values personal respect and professional achievement based on the highest intellectual and ethical standards. The job advertisement is also published on our website www.lih.lu/jobs.
Applications including a cover letter and curriculum vitae should be sent before 1st February 2021 through our website www.lih.lu/jobs : CM/PDCBG1220/SN/Norlux
Post-doctoral position in pharmacogenomics for glioma, Luxembourg
Luxembourg Institute of Health (LIH) is the leading public research center in Luxembourg for basic, pre-clinical and clinical research in biomedicine and public health. Our clinically-oriented biomedical research activities in Oncology, Infection & Immunity and Population Health encompass the generation of knowledge on the pathogenesis, diagnosis and treatment of diseases with large impacts on public health and the epidemiological surveillance of these diseases. With the mission to deliver scientific, economic and societal value for Luxembourg, LIH aims to translate knowledge into clinical applications impacting on healthcare systems while shaping personalized medicine.
To be part of the NORLUX Neuro-Oncology Laboratory (Group leaders: Prof Simone Niclou and Dr. Anna Golebiewska) within the Department of Oncology
Post-doctoral position in pharmacogenomics for glioma
3-year fixed-term contract, full time. Start date: April 2021.
Background. Diffuse gliomas are the most frequent and most dismal primary brain tumours in adults. Gliomas undergo cellular and molecular evolution during disease progression, which is only partially explained by genetic evolution, suggesting that transcriptional and epigenetic changes may be the basis of cellular adaptation processes. The international GLASS (Glioma Longitudinal AnalySiS) initiative, aims to systematically catalogue the temporal changes in gliomas at the genetic, epigenetic and transcriptomic levels. In this context, NORLUX aims to assess differential functional drug responses of primary versus recurrent gliomas.
Objectives. By combining mulitomics molecular characterisation and high content drug screens on ex vivo patient-derived glioma organoids from paired longitudinal tumors, we aim to determine differences in drug sensitivity and predict personalized treatment options for recurrent glioma patients. Patient-derived orthotopic xenografts (PDOX) will be applied for in vivo validation studies.
Training and research environment. The NORLUX lab is a dynamic, multinational and interdisciplinary team focusing on the biology of malignant brain cancer. It is part of the Department of Oncology and uses cutting edge technologies, including genomic, metabolomic and proteomic analyses, single cell technologies (single cell RNA-Seq, CYTOF, Imagestream) as well as state-of-the-art preclinical models. The project will be performed in collaboration with the international GLASS consortium (www.glass-consortium.org/). The post-doctoral fellow will be supported through a FNR CORE funded project and will join an interdisciplinary project team, including cellular and molecular biologists, animal experts, bioinformaticians and statisticians. Recent related reference: https://pubmed.ncbi.nlm.nih.gov/33009951/
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as opportunities for conference attendance and collaborations with other research organisations.
Scientific contact
Prof Simone Niclou, PhD
84 Val Fleuri
L-1526 Luxembourg
LUXEMBOURG
simone.niclou@lih.lu
Key Skills, Experience and Qualifications
- PhD in Molecular Biology or Biomedical Sciences with experience in cancer research.
- Experience in molecular biology and genome-wide molecular profiling is required. Previous experience in drug screening, epigenetics (ATAC-seq), multi-omics analyses and imaging is desirable.
- Animal experimentation diploma (FELASA or equivalent) will be an asset.
- Independent and self-motivated person, scientific creativity and originality, strong team spirit and collaborative capacity, excellent time management, rigor, perseverance, strong writing skills.
- Fluency in English is mandatory
More information about the group can be found here : https://norlux.lih.lu
Located in Luxembourg, LIH offers the opportunity to work in a dynamic, international and multilingual
environment that values personal respect and professional achievement based on the highest intellectual and ethical standards. The job advertisement is also published on our website www.lih.lu/jobs.
Applications including a cover letter and curriculum vitae should be sent before 1st February 2021 through our website www.lih.lu/jobs : CM/PDPG1220/SN/Norlux
