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A s previously announced, the COVID pandemia had forced us to cancel the 2020 EANO meeting, to be held in Glasgow UK, September 10-13, 2020. Still, a lot of highly relevant research has appeared during the past year, and there is a continuous need for education. We have therefore decided to transition a part of the Glasgow meeting into a series of 3 webinars:

  • I. EANO webinar on Cancer Neuroscience: on neurons, glioma and the immune system, September 9, 2020 16:00-17:30 (CEST)
  • II. EANO webinar on Brain metastatic disease in the targeted era: improved outcome by changed strategies, September 10, 2020 16:00-17:30 (CEST)
  • III. Joint EANO-EAN Webinar on Neurotoxicity from antineoplastic treatments, September 11, 2020 16:00-17:30 (CEST)
  • EANO webinar on Psycho-social support interventions for patients and caregivers, September 23, 2020 16:00-17:30 (CEST)

⇒Click here to book you place!

Further eEANO webinars to come!

Psycho-social support interventions for patients and caregivers

An increasing number of studies have documented both the experiences and needs of patients and families who are living with a primary malignant brain tumor. These studies provide a strong rationale for testing the effects of a variety of complex interventions. Examples of promising supportive care interventions include home-based psychosocial interventions, internet-based and telehealth solutions, family camps, and several promising informational materials.

Internationally, we have dedicated neuroscience nurses, neuropsychologists, and AHPs who coordinate and lead research and clinical practice to continually improve the quality of life of the patients with a brain tumor and the neuro-oncology caregiver. Still, we need to strengthen our delivery of supportive-care strategies to ensure that they are based on an evidence-based systematic approach that spans the disease trajectory from diagnosis until end-of-life as well as ensure proper support for the bereaved.

Opens internal link in current windowJoin the eEANO webinar on the 23rd September to learn about the psychological adjustment and supportive care needs of patients with a brain tumor and their caregivers and how to address these. Participating in this webinar will inspire attendees to establish supportive care interventions to optimize the quality of life for our patients and their relatives.

References:
Ownsworth, T, Chambers, S. Damborg, E, Casey, L. Walker, D., Shum, D. Evaluation of the making sense of brain tumor program: a randomized controlled trial of a home-based psychosocial intervention. Psycho-Oncology 24: 2015.
Page, M. The UCSF Neuro-Oncology Gordon Murray Caregiver Program, an example of successful integration of caregiver support into the neuro-oncology clinic. (2019)
https://www.acnr.co.uk/2019/11/the-ucsf-neuro-oncology-gordon-murray-caregiver-program-an-example-of-successful-integration-of-caregiver-support-into-the-neuro-oncology-clinic/
Boele, F. W., Klein, M., Verdonck-de Leeuw, I. M., Cuijpers, P., Heimans, J. J., Snijders, T. J.,  Vos, M., Bosma, I., Tijssen, C., & Reijneveld, J. C. (2018). Internet-based guided self-help for glioma patients with depressive symptoms: a randomized controlled trial. Journal of neuro-oncology, 137(1)
Piil K, Jakobsen J, Christensen KB, et al. Needs and preferences among patients with high-grade glioma and their caregivers – A longitudinal mixed-methods study. Eur J Cancer Care. 2018

Immunotherapy for glioblastoma: still a long way to go

The emergence of immune checkpoint inhibitors has led to a revolution in the therapeutic management of various types of cancer. Therefore, there was great hope that these drugs would also be active against primary brain tumors such as glioblastoma. The CheckMate 143 trial is the first completed randomized study to evaluate an immune checkpoint inhibitor in patients with recurrent glioblastoma. The main results of the trial, that is, the lack of a survival benefit of the PD-1 inhibitor nivolumab compared to bevacizumab, had been known for some time. Now, the full report on this trial is available (see publication link below). The overall disappointing results suggest that "all-comers strategies" are most likely not the right approach to implement immunotherapy as a successful treatment strategy against glioblastoma. A subgroup analysis suggests that patients with MGMT promoter-methylated tumors who had not received steroid therapy at the time of enrolment, may have benefited more from nivolumab than from bevacizumab. In view of the small number of patients in these analyzes, these data must be interpreted with caution. Overall, a comprehensive and careful analysis of the dataset of this and similar studies is mandatory to improve the design of future clinical trials assessing immune checkpoint inhibitors or other immunotherapeutic approaches in glioblastoma patients.

Reference: Reardon DA, Brandes AA, Omuro A, et al. Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial. JAMA Oncol. 2020;6(7):1003–1010. Opens external link in new windowdoi:10.1001/jamaoncol.2020.1024

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Participate in an international survey

Prescription preferences of antiepileptic drugs (AEDs) in brain tumor patients: an international survey

Antiepileptic drugs (AEDs) are the cornerstone of therapy in patients with brain tumor related epilepsy. The number of different AEDs has significantly increased over the past 30 years. To get more insight into the current prescription preferences among the neuro-oncological community, Dr. Johan Koekkoek and Dr. Roberta Rudà have composed a short survey on AED use in brain tumor patients.
We would very much appreciate if you take the time to fill in the questionnaire, it only takes  5-10 minutes.

Thank you for your participation!
Click here for participation

Update on Neurosurgical oncology

Neurosurgical management of patients with brain tumors consist of some long-standanding controversies. One such controversy is whether performing a so-called supramarginal resection in patients with glioblastoma offers a significant survival benefit. A supramarginal resection can pragmatically be defined as anything beyond the contrast enhancing tumor, making the resection cavity larger than the contrast enhancing tumor was in the first place. Current evidence consist of retrospective case-series and the most recent systematic review on the topic was recently published in Journal of Neuro-oncology by Jackson et al. from Johns Hopkins (Opens external link in new windowdoi.org/10.1007/s11060-020-03556-y), and they reached a similar conclusion to previous reviews that supramarginal resections seems associated with prolonged survival. In this review, they emphasize that a more anatomical resection (e.g. anterior temporal lobotomy) may be more beneficial than just extending margins.

Interestingly, to better answer the controversy a European randomized study on the topic of supramarginal resection has just opened (www.supramarginaltrial.com) and is recruiting.

Neurosurgical oncology is not only about prolonging life. Another crucial aspect of is to preserve function and recently an excellent paper of the so called “triple motor mapping” was published by Gogos and co-workers from UCSF in Journal of Neurosurgery (Opens external link in new windowdoi.org/10.3171/2020.3.JNS193434). In experienced hands this technique allows for safe resection of tumors near the motor cortex and corticospinal tract with surgery under general anesthesia. The publication has nice illustrations for demonstration of this highly useful technique. 

Advancing personalised cancer treatment through patient “avatars”

Orthotopic patient-derived brain tumour models available on PDXFinder supporting the worldwide use of these key tools for translational brain tumour research.

In order to study tumor evolution and drug response, and thereby develop novel therapeutic options, experimental models that accurately represent a patient’s tumour are of utmost importance in the preclinical setting. A comprehensive cohort of over 40 Patient-Derived Orthotopic Xenografts (PDOXs) of malignant gliomas has now been made publicly available on PDXfinder, an open global PDX model catalogue co-developed by the European Molecular Biology Laboratory - European Bioinformatics Institute (EMBL - EBI) and the Jackson Laboratory and supported by the EuroPDX consortium.

These glioma PDOXs consist of human tumour organoids – three-dimensional tissue cultures derived from viable cells from patient tumours – which are subsequently implanted in immunodeficient mice. These models act as clinically relevant patient “avatars”, faithfully reflecting the main biological, histological and genomic features of the original patient tumor. The currently available data includes patient information, such as gender, age, diagnosis, type (primary/recurrent), site and grade. The remaining information, such as the genetic and molecular characteristics, methods of implantation, tumor histology, drug response and quality assurance methods, will be available soon.

The glioma PDOX cohort includes primary and recurrent gliomas, at different stages, from different subtypes and carrying different mutations. It also includes longitudinal PDOXs derived from tumour samples of the same patient prior to and after treatment, which constitutes an invaluable research tool to study glioma progression and treatment response. The cohort has been contributed by the NORLUX Neuro-Oncology Laboratory from the Luxembourg Institute of Health.

The Brain Tumour Patients’ Charter of Rights

The International Brain Tumour Alliance (IBTA) has released the 'Brain Tumour Patients' Charter of Rights', to achieve the best possible health and quality of life outcomes for adults and children living with a brain tumour. A document supported by EANO and over 70 international organisations, to represent an aspirational ideal against which quality standards, policies and practices are developed, monitored and delivered. Goals aiming to reduce inequalities from country to country and support better outcomes.

Systematic treatment of brain metastases in non-small cell lung cancer: an increasingly complex area of high clinical importance

In the past decade, prognosis of patients with brain metastases has improved, both by improved local treatments but in particular by more effective systemic treatments. Moreover, because of this improving survival, more patients are at risk to develop brain metastases. And, as another consequence, the role of local treatments is increasing significantly. This makes the approach to patients with brain metastases much more complex and challenging, and raises questions about how to best combine stereotactic radiotherapy with systemic treatments.

In an excellent overview by Page et al results from studies on systemic treatment alone and in combination with local radiotherapy of patients with brain metastasis from non-small cell lung cancer are reviewed. The authors present a state of the art overview of the efficacy of novel targeted and immunological treatments  for NCSLC patients with brain metastases, alone and in combination with local radiotherapy and provide recommendations for future trials as more evidence is clearly needed. And approaches may actually differ for the various mutational NSCLC subtypes. Retrospective data suggest that especially in EGFR mutant tumors there may be benefit if tyrosine kinase inhibitors are combined early with local radiotherapy. Similar question now rise in NSCLC patients with brain metastases treated with immunotherapy. This review nicely captures the many sides of this problem, which urgently requires answers.

Reference: Page, S., Milner-Watts, C., Perna, M. et al. (2020). 'Systemic Treatment of Brain Metastases in Non-Small Cell Lung Cancer', European Journal of Cancer, 132 (June), pp. 187-198 PMID: 32380429 Opens external link in new windowDOI: 10.1016/j.ejca.2020.03.006

Perioperative imaging in brain metastases: EANO Youngsters publication

The EANO Youngsters have performed an international survey on perioperative imaging routines in brain metastasis patients.  A standardized questionnaire was distributed in the EANO network and was completed by 120 physicians. The results show high variability in imaging procedures in the perioperative management of brain metastasis patients with regard to imaging modalities and time-points.  The results from this study highlight the need for standardisation of clinical routines in patients with brain metastases.

Reference: Kiesel, B., Thomé, C.M., Weiss, T. et al. Perioperative imaging in patients treated with resection of brain metastases: a survey by the European Association of Neuro-Oncology (EANO) Youngsters committee. BMC Cancer 20, 410 (2020). Opens external link in new windowdoi: 10.1186/s12885-020-06897-z.

EANO Glasgow Postponed

Dear friends, dear colleagues

A few weeks ago, we announced that we were continuing to work on EANO 2020, hoping that by September 2020 the circumstances would allow this major European neuro-oncological event to happen. However, it is clear that even now when restrictions are gradually lifted many uncertainties about the COVID infection rate will remain over the entire summer period. Unpredictable travel limitations, unclear national policies on mass gatherings, and the chance of yet another surge in COVID infections make a productive and successful face-to-face EANO 2020 in early September unlikely. Therefore, we have taken the difficult decision to postpone the EANO 2020 Meeting in Glasgow to another year.

We have decided to develop a series of webinars instead, called eEANO, through which we will bring neuro-oncological updates to the EANO membership. These will start on September 10-13, the original dates of EANO 2020. We will continue eEANO as a series of webinars afterwards, which will be CME credited, for members only. We intend to provide both educational content and the latest scientific developments on clinical trials and laboratorial research as a continuing programme. Topics will be developed in collaboration with the membership. More information will be provided once we have finalized the details. The next planned EANO Meeting should take place in 2021. We will keep you posted on that situation and very much hope to welcome you to a ‘face-to-face’ conference next year.

I am very sorry not to see you in person in Glasgow this summer; not meeting colleagues is yet another loss that many of us deplore. I also apologize for not informing you earlier, but as you can imagine it has been complicated to reach a good solution with regard to the practical issues. Lastly, I want to recognize the many people who have worked hard to prepare the 2020 meeting, in particular our local chair Anthony Chalmers.  EANO is scheduled to come to Glasgow in 2024!

On behalf of the EANO board,
Martin van den Bent
EANO President

Hot of the press EANO Annual Report 2019

The EANO Executive Board is glad to present this year's EANO Annual Report. It gives you an overview on what we have done during 2019 and on our planned activities for 2020 as well as important developments in Neuro-Oncology in Europe.

For the new EANO Annual Report 2019 click here

Most Popular Scientific Neuro-oncology Papers in 2019

According to the EANO Youngsters

The EANO Youngsters selected the most important scientific neuro-oncology papers of 2019. Instead of just looking at the number of citations or impact factors, we performed a survey in our EANO Youngsters Facebook group. We received a lot of input! We now have an interesting impression of which studies our followers were most interested in this year.
This year's list features important basic science papers, published in high-impact journals, and possible practice-changing clinical papers.

So, here are our top 6 paper:

  1. Suva group's single cell paper: Neftel C. et al. (2019) An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. Cell, 178(4):835-849.e21. doi: 10.1016/j.cell.2019.06.024. https://www.ncbi.nlm.nih.gov/pubmed/31327527
  2. The Nature-trio on synaptic interactions between glioma cells and neurons: Barrier A. Dangerous liaisons as tumour cells form synapses with neurons. Nature (2019) 573, 499-501, doi: 10.1038/d41586-019-02746-7 https://www.nature.com/articles/d41586-019-02746-7
  3. Taylor group's snRNA paper: Suzuki H. et al. . Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma. Nature. (2019). doi: 10.1038/s41586-019-1650-0. https://www.ncbi.nlm.nih.gov/pubmed/31597162
  4. Exciting work from the Glioma Longitudinal Analysis (GLASS) Consortium: Barthel, F.P., Johnson, K.C., Varn, F.S. et al. Longitudinal molecular trajectories of diffuse glioma in adults. Nature (2019) doi:10.1038/s41586-019-1775-1 https://www.nature.com/articles/s41586-019-1775-1
  5. Whole brain radiotherapy with or without hippocampal avoidance in brain metastases: Tomé W. et al. RADI-11. NRG ONCOLOGY CC001: A PHASE III TRIAL OF HIPPOCAMPAL AVOIDANCE IN ADDITION TO WHOLE-BRAIN RADIOTHERAPY (WBRT) PLUS MEMANTINE TO PRESERVE NEUROCOGNITIVE FUNCTION IN PATIENTS WITH BRAIN METASTASES (BM), Neuro-Oncology Advances, Volume 1, Issue Supplement_1, August 2019, Pages i23–i24, doi.org/10.1093/noajnl/vdz014.104 https://academic.oup.com/noa/article/1/Supplement_1/i23/5546283
  6. Lomustine-temozolomide or standard temozolomide therapy in glioblastoma: Herrlinger U. et al. Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA–09): a randomised, open-label, phase 3 trial. The Lancet (2019) 393 (10172), P678-688, doi.org/10.1016/S0140-6736(18)31791-4 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31791-4/fulltext?dgcid=raven_jbs_etoc_email

Thank you very much for being with us in Lyon for attending the EANO 2019

Dear friends and colleagues,

It was a great pleasure to welcome all of you in Lyon, and make the EANO 2019 a great meeting increasing our knowledge to take care of patients with brain tumors. More than 750 participants from 50 different countries and from all the continents participated to the 14th EANO meeting. All the specialties were equally represented with a good percentage of nurses. The scientific presentations showed up a large variety of important subjects in the field of neuro-oncology and was the opportunity to listen to high level lectures about immunology, low-grade glioma, omics in neuro-oncology, microenvironment, neurological complications of cancer or brain lymphoma. It was also wonderful to see the involvement of young neuro-oncologists in the EANO meeting and organization. The diversity of age and origin of the participants is really a good sign that EANO annual meetings have become a meeting for everybody and able to attract colleagues from all continents.

The 14th EANO meeting was also the opportunity to discover Lyon, a European city at the crossroads of Europe, listed by UNESCO as a world heritage site with the remains of 20 centuries of History. The participants discovered the high level of gastronomy of the city with its 14 starred restaurants and to the typical and charming bistros called “Bouchons”. The networking evenings have been the opportunity to visit the City Hall and to have a wonderful cruse with a seated dinner on the Rhone and the Saone.

We were very happy when France and Lyon were given the responsibility for EANO 2019, and it has been a real pleasure to interact with all the members of the EANO executive Board and the EANO scientific committee to construct the program and to organize the meeting.

Many thanks for your contribution and I will be very happy to meet you in Glasgow in September 2020.

Jérôme Honnorat, President EANO 2019 Meeting

EANO 2019 all presentations are online

EANO members can find a large selection of presentations from the EANO 2019 Meeting online in the login area!

Neuro-Oncology Practice is now fully indexed in PubMed Central®

The European Association of Neuro-Oncology (EANO) and  Society for NeuroOncology (SNO) the  are pleased to announce that their journal, Neuro-Oncology Practice, is now fully indexed in PubMed Central® (PMC). All content published in Neuro-Oncology Practice, starting with the first issue, has been deposited in PMC and is now discoverable through PubMed®. PMC is a free archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM).

Indexing in PMC and discoverability via PubMed provides increased access to articles for the scientific and clinical communities, and marks its continued success, high-quality articles, and the diversity and excellence of the editorial board and authors. The Journal can be accessed here: https://academic.oup.com/nop (includes Advance Access articles), and can also be accessed on the PMC site here: https://www.ncbi.nlm.nih.gov/pmc/journals/2697/

It has been great to partner with SNO, EANO and OUP to grow the journal and provide the neuro-oncology community with valuable resources pertinent to patient care,” said Dr Susan Chang, Editor in Chief of Neuro-Oncology Practice and Professor of Neurological Surgery at the University of San Francisco, CA, United States, “I know authors and readers will be happy that articles from Neuro-Oncology Practice will be discoverable via PubMed.”

Published in partnership with Oxford University Press, Neuro-Oncology Practice focuses on the clinical aspects of the subspecialty for practicing clinicians and healthcare specialists from a variety of disciplines including physicians, nurses, physical/occupational therapists, neuropsychologists, and palliative care specialists, who have focused their careers on clinical patient care and who want to apply the latest treatment advances to their practice.

For more information and to submit a manuscript for consideration, visit https://academic.oup.com/nop and follow the journal via Twitter at https://twitter.com/neuroonc and at https://twitter.com/eanoassociation

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