The complications associated with brain tumours require specific management strategies for optimal prevention, diagnosis, therapy and follow-up, and necessitate multidisciplinary cooperation. The current European Association of Neuro-oncology (EANO)-European Society for Medical Oncology (ESMO) joint guidelines summarise recommendations for the clinical management of the most important complications observed in brain tumour patients and cover brain oedema, seizures, neurocognitive impairment, venous thromboembolism, stroke, intracranial haemorrhage, metastatic spinal cord compression (MSCC) and supportive and end-of-life care. Due to the lack of high-level evidence on these topics, most recommendations are based on expert opinion and consensus. They aim at guiding clinical management of brain tumour patients and end-of-life care and serve as a helpful resource for physicians and health care providers. For the future, prospective clinical trials specifically enrolling brain tumour patients are needed to better define diagnostic and therapeutic measures of complications in this patient group.
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